BIFIDOBACTERIUM LACTIS HN019™

Introduction

B. lactis HN019™ has been consumed in dairy foods for decades and is well-studied for its probiotic properties in more than 111 scientific publications.  It has been demonstrated to tolerate acidic conditions and shown to survive passage through the human intestine.^1-3 Mechanistic data suggests HN019™ may influence colonic motility, and multiple clinical trials with HN019™ alone or in combination with prebiotics or other probiotic strains have resulted in increased gut transit in persons with less frequent bowel movements.^4-6 HN019™ has also been shown to modulate immune function, particularly enhancing cellular immune activity in aging persons.⁷

REFERENCES:
1. Gopal PK, Prasad J, Gill HS Effects of the consumption of Bifidobacterium lactis HN019 (DR10 TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutrition Research. 2003;23:1313-1328. 2. Prasad J, Sazawal S, Dhingra U, Gopal PK Detection of viable Bifidobacterium lactis HN019 (DR10TM) in stools of children during a synbiotic dietary intervention trial. Intl Dairy J. 2013;30:64-67. 3. Wickens K, Black PN, Stanley TV, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clinical Immunology. 2008;122:788-794. 4. Dalziel JE, Anderson RC, Peters JS, et al. Promotility action of the probiotic Bifidobacterium lactis HN019™ extract compared with prucalopride in isolated rat large intestine. Frontiers in Neuroscience. 2017; 11. 5. Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019™ supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled and dose-ranging trial. Gut Microbes. 2017; Dec 11:0. 6. Waller PA, Gopal PK, Leyer GJ, et al. Dose-response effect of Bifidobacterium lactis HN019™ on whole gut transit time and functional gastrointestinal symptoms in adults. Scandinavian J Gastroenterology. 2011;46:1057-1064. 7. Miller LE, Lehtoranta L, Lehtinen MJ. The Effect of Bifidobacterium animalis ssp. lactis HN019™ on cellular immune function in healthy elderly subjects: systematic review and meta-analysis. Nutrients. 2017;9:191.