HOWARU® Shape

HOWARU® Shape

HOWARU® Shape

The study published in the world-renowned journal, EBioMedicine, showed that HOWARU® Shape (Bifidobacterium lactis 420) in combination with the dietary fiber Litesse® Ultra™ polydextrose (LU) achieved effective weight management.

The 6 months of double-blind, parallel clinical trial investigated the possible effects of Bifidobacterium animalis ssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra™ polydextrose (LU) on body fat mass and other obesity-related parameters. 225 healthy volunteers (healthy, BMI 28–34.9) were randomized into 4 groups (1:1:1:1), using a computer-generated sequence: 1) Placebo 2) LU 3) B420 4) LU + B420. With dual-energy X-ray absorptiometry, body fat mass was measured comparing treatment groups to the placebo, while anthropometric measurements and food intake were also included in the outcomes.

Data showed that LU + B420 and B420 reduced body fat mass, trunk fat mass, waist circumference and energy intake[1]. Compared to the placebo, LU + B420 showed a 4.5% decrease in body fat mass, 6.7% decrease in trunk fat mass and an 1 inch (2.6 cm) reduction in waist circumference.

Reference:

Stenman, Lotta K.; Lehtinen, Markus J.; Meland, Nils, Christensen; Jeffrey E., Yeung, Nicolas; Saarinen, Markku T.; Courtney, Michael; Burcelin, Rémy ; Lähdeaho, Marja-Leena; Linros, Juri; Apter, Dan; Scheinin, Mika; Kloster Smerud, Hilde; Rissanen, Aila; Lahtinen, Sampo; Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial, EBioMedicine (2016; 13: 190-200), doi: 10.1016/j.ebiom.2016.10.036.
https://www.ebiomedicine.com/article/S2352-3964(16)30497-2/fulltext
1 Probiotics Patent family: WO2010/146568 and WO2011/013106 European patent applications filed April 2016: EP16165376 + EP16165379